The modern fat burner INCINDERINE
I think all of us desire to have a solid physique but most people find it difficult to really get into shape. Having an ultra low bodyfat percentage along with some solid muscle mass is the ultimate goal. BLR makes the best natural muscle growth supplements so we have that covered but once you gain that muscle its time to peel the fat off and reveal your shredded physique.
Burning fat is tough but really getting into the low single digits is exceptionally difficult.
No longer.
Introducing INCINDERINE
Incinderine is a potent dual GLP-1/GIP agonist with combined DPP-4 inhibition. Ill explain this shortly but in addition to this we have multiple other MOAs making this the most powerful fat burner available.
Easily as powerful as Pharma counterparts and likely more powerful as Incinderine is not limited to 1 MOA. So lets take a look.
MYRICETIN CYCLODEXTRIN COMPLEX
Myricetin is a member of the flavonoid class of polyphenolic compounds, with antioxidant properties. Common dietary sources include vegetables, fruits, nuts, berries, tea, and red wine. Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as these other members of the flavonol class of flavonoids. Myrecetin is an exceptionally potent flavonoid with a host of beneficial effects on health but for our purposes we are specifically concerned with its ability to help us lose bodyfat.
Myricetin is a POTENT GLP-1 agonist comparable in strength and effects to the prescriprion GLP-1 agonist Liraglutide (REF 1.) And showed more potent effects on insulin and fat loss than injected GLP-1.
QUOTE"the rats injected with myricetin exhibited better glucose tolerance in this single-dose injection experiment than those treated with GLP-1. The treatment with myricetin resulted in blood glucose levels that were main-tained at 7.5–8.5 mM over 8 h, and these results were similar to those after liraglutide administration. Additionally, myricetin seemed to exhibit a similar glucoregulatory duration(0–8 h), which suggests that myricetin might possess a half-life similar to that of liraglutide (11.3 h) "
It would appear that Myricetin is an exceptionally potent GLP-1 agonist, as effective as prescription drugs of this type and more potent than GLP-1 itself at managing insulin but there is more.
DPP-4
Dipeptidyl-peptidase 4 (DPP4) is a glycoprotein, which is ubiquitously expressed on the surface of a variety of cells. This exopeptidase selectively cleaves N-terminal (Peptide Bond) dipeptides from a variety of substrates, including cytokines, growth factors, neuropeptides, and the incretin hormones. Expression of DPP4 is substantially dysregulated in a variety of disease states including inflammation, cancer, obesity, and diabetes. Since the incretin hormones, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GIP), are major regulators of post-prandial insulin secretion, inhibition of DPP4 by the gliptin family of drugs has gained considerable interest for the therapy of type 2 diabetics. DPP-4 inhibitors prevent the N-terminal cleavage and the destruction of the Incretins GLP-1 and GIP. Myricetin is a potent DPP-4 inhibitor so on top of its ability to increase the secretion of GLP-1 it also prevents its destruction which is part of why Myricetin is shown to be more powerful than GLP-1 itself!
GIP
Glucose-dependent insulinotropic polypeptide (more commonly known earlier as gastric inhibitory polypeptide or gastric inhibitory peptide), abbreviated as GIP, is an inhibiting hormone of the secretin family of hormones. While it is a weak inhibitor of gastric acid secretion, its main role, being an incretin, is to stimulate insulin secretion. Recently the pharamaceutical industry has been working hard to improve on the already extremely effective GLP-1 agonist. In 2022 Eli Lily announced the next generation of these far burning drugs with Mountjaro. The first Combination GLP-1 and GIP agonist. This combination has been shown to decrease weight by significantly more than semaglutide and other GLP-1 agonists.
Weight reduction: 11.2 kg (24.7 lb., Mounjaro 15 mg), 6.9 kg (15.2 lb., injectable semaglutide 1 mg) and 0 kg (placebo), p<0.001
Fat mass reduction: 9.7 kg (21.4 lb., Mounjaro 15 mg) and 5.9 kg (13.0 lb., injectable semaglutide 1 mg), p=0.002
Keep in mind neither of these drugs have the added DDP-4 inhibitor so we have even more power in Incinderine.
ok so we have Massive potential as a GLP-1 and GIP inhibitor coupled with DPP-4 inhibition but thats just the beginning.
Myricetin also increases insulin sensitivity which further accentuates the weight loss potential of the previously discussed mechanisms as GLP-1 agonists. GIP agonists and DPP-4 inhibitors all help boost insulin.
Myricetin also activates BAT (brown adipose tissue AKA brown fat) and Beige Fat by upregulating thermogenic protein expression and activating mitochondrial biogenesis, eventually increasing heat dissipation and calorie expenditure. This is exceptionally important for those of us looking to burn body fat. In order to demonstrate why we need a bit of education regarding the different types of fat.
There are different types of fat in your body. Each type is identified by its color and function, including:
Most of the fat in your body is white fat. White fat stores energy in various places around your body. White fat insulates your organs. Too much white fat leads to obesity.
Brown fat: This is the type we want.
Brown fat is smaller than white fat. It stores energy and burns that energy to regulate your body temperature. Brown fat helps you burn calories by creating heat right before your body starts to shiver (thermogenesis). It also helps regulate sugar (glucose) and fat metabolism.
Beige fat: This type is also beneficial because it is basically white fat preparing to convert to the brown fat.
Beige fat is a combination of white and brown fat cells. These cells burn calories to regulate body temperature by converting white fat cells to brown.
Converting our white fat to brown fat is massively important to getting super us shredded. Brown fat is not fat like we would think of it. Its an absolute lean physique shredding powerhouse that instead of storing the calories we eat it burns them off like a furnace. So we want as much of this as possible. Increasing the conversion rate of white fat to beige and brown causes the body utilize excess calories and burn them off vs storing them.
For the sake of brevity I will just quickly mention some additional benefits.
Myricetin is a relatively potent aromatase inhibitor and the reduction in estrogen will assist in reducing bodyfat and water retention. Myricetin is a PDE inhibitor, reduces LDL and my favorite, increases the release of endorphins which really helps push through when you are training to failure and dieting. It also has a host of antiaging and general health benefits.
Myricetin has one drawback....it has a roughly 10% oral bioavailability. Studies indicate that complexing myricetin with specific cylodextrins can increase oral bioavailability by 900%. So our Myricetin cyclo complex is 900% more potent than plain myricetin and Incinderine also employs Biox which increases bioavailability and reduces metabolism in vivo even further.
Oleanolic acid is a naturally occurring pentacyclic triterpenoid related to betulinic acid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins. Oleanolic acid is an interesting fat burner that shares some of its effects with other triterpenoids like ursolic acid. For example oleanolic acid is a Takeda G protein-coupled receptor 5 (TGR5) agonist. An interesting finding for TGR5 is its role in energy metabolism. The discovery of TGR5 expression in brown adipocyte tissues (BATs) and the recent demonstration of BAT in adult human body suggest a potential approach to combat obesity by targeting TGR5 to increase thermogenesis. Endogenous TGR5, regulates glucose metabolism. In animals, TGR5 activation by a chemical agonist leads to an increase in GLP-1 which helps Oleanolic acid work together with Myricetin for GLP-1 receptor modulation.
Oleanolic acid treated obese mice exhibited a decrease in body, liver, and visceral adipose tissue weights. Oleanolic acid treatment improved glucose tolerance, insulin level, plasma lipopolysaccharide (LPS), and hepatic cholesterol and triglyceride concentrations.
Oleanolic acid increases the mRNA encoding of CD36, a fat taste receptor, in taste bud cells. This gives us a preference toward fatty foods vs sugary ones which is preferential for fat loss. Expression of CD36 is regulated at both the transcriptional and posttranslational levels, but regulation differs among different cell types. Similar to many other genes involved in lipid metabolism, CD36 expression in fat and muscle is upregulated by the nuclear hormone transcription factor PPAR-ɣ. Studies have indicated that CD36 links extracellular signals to intracellular fatty acid metabolism and redox metabolism in both innate and adaptive immune cells, impacting their fate and activation. Similar mechanisms operate in hematopoietic stem cells and tumor initiating cancer stem cells where CD36 expression promotes and maintains “stemness” by sensing extracellular ligands, including oxidized phospholipids, and by facilitating fatty acid uptake from surrounding adipose tissues to fuel fatty acid oxidation. The laymens version of this is CD36 reduces craving for sugar, increases fat metabolism and helps increase the uptake of adipose tissue specifically to be utilized for fuel. This is also part of how we see the increase in brown fat from Oleanolic acid.
Oleanolic acid also influences the expression of mRNA encoding pro-inflammatory cytokines (IL-1β and IL-6) and some lipogenic genes (PPARα, SREBP1, FAS, ChREBP, and G6Pase) in liver and adipose tissue. These are well known fat burning pathways that help contribute to the fat burning effects of this powerful ingredient. Its also very effective at reducing Reactive oxygen species which helps prevent DNA and RNA damage. In addition Oleanolic acid shows protective benefits against mitochondrial damage and activates macrophages to assist with boosting the immune systems response to exercise, helps to repair muscle faster after training and increases mineral bone density.
Unfortunately Oleanolic acid has very poor oral bioavailability with its absolute bioavailability to be approximately .7%. Not 7%... .7%. This makes it basically inert orally so we had to modify it to make it orally bioavailable. Not all compounds are suitable for all methods. Oleanolic acid tends to have a very poor bond with cyclodextrins so we opted for phospholipid complex which significantly increases bioavailability, and, Incinderine employs our bioavailability complex BioX which gives additional potency. There is no oleanolic acid product available that works this well period.
Berberine is an isoquinoline alkaloid with a long history of use in Ayurvedic and traditional Chinese medicine for the management of various health conditions. Its potent ability to reduce blood sugar rivals that of some anti-diabetic drugs.
Berberine is known to improve glucose and lipid metabolism disorders, but it poorly absorbed into the blood stream from the gut.
GLP-1 release
Previous studies revealed that berberine-mediated GLP-1 secretion was a possible mechanism for berberine exerting good effects on hyperglycemia. The activation of (TAS2 receptors) bitter taste receptor by berberine causes the release of GLP-1. In addition Berberine increases mitochondrial function in L-cells within the epithelial layer of the intestine mucosa and increased secretion of GLP-1 in the gut.
